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pDCs, plasmacytoid dendritic cells, IFN, interferon, DAMPs, damage-associated molecular patterns

However, the antitumor efficacy of platinum chemotherapeutic drugs comes at the cost of nephrotoxicity and ototoxicityside effects that remain major clinical limitations (84

15 Research gaps and roadmap for clinical translation Although apigenin and ellagic acid demonstrate strong promise in preclinical and limited clinical settings, critical research gaps remain before they can be integrated into evidence-based management of PCOS

Oxidative stress is the major pathogenic factor of AIH, and the Keap1-Nrf2 pathway is the main defense mechanism against oxidative stress

Zhang HJ, Deng AJ, Zhang ZH, Yu ZH, Liu Y, Peng SY

These findings indicate a bidirectional hostmicrobial signaling that regulates gut microbiota colonization via the serotonergic system