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Figure 1 2 The cardiac macrophage landscape in sepsis 2.1 Origin and heterogeneity of cardiac macrophages The heart harbors a diverse population of macrophages originating from two primary lineages: embryo-derived resident macrophages and monocyte-derived macrophages recruited from the circulation ( - populations) self-renew and help maintain tissue homeostasis, whereas circulating monocytes (e.g., CCR2 + populations) are recruited in response to injury or inflammation ( Figure 2 )

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