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This dual role of lactate in modulating ferroptosis and inflammation may account for the inconsistent therapeutic outcomes associated with hypertonic sodium lactate administration in sepsis, as these effects appear to be highly dependent on factors such as timing of intervention, dosage and the specific experimental animal models employed (104,109)

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10.18632/aging.101496 11 ChongY.LiJ.LiuX.WangX.HuangJ.YuN.et al (2021)

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Proc Soc Exp Biol Med 152: 610614 Phelps BH, Varandani PT (1977) Stimulation by insulin of cyclic AMP phosphodiesterase