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DOI: 10.1371/journal.pone.0035054 9

Moreover, high ROS levels causes injury on mitochondrial function, which can trigger the intrinsic apoptotic pathway in oocytes and granulosa cells (Dai et al., GPX1 -transcript abundance is involved in the reduction of intracellular ROS concentration, the activation of the apoptosis cascade would be reduced, which would agree with the observed decrease in the relative BAX -transcript abundance

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Circulation 100:354360

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Emerging evidence highlights the dual role of nutraceuticals in modulating drug efficacy and toxicity