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If your liver is constantly busy dealing with "leaks" from the gut, it has less capacity to deal with other environmental stressors

Therefore, there is also a need for well-designed disease-specific clinical trials that take into consideration the dietary and genetic determinants of FOCM to clarify the contribution of FOCM to neurodegeneration and to help in the development of targeted therapeutic strategies

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J Clin Psychiatry 2014;75:628-36

In this study, we bridge these knowledge gaps by investigating how FPN deficiencyinduced hepatic iron overload reprograms hepatokine secretion to drive systemic metabolic dysfunction

For more on this topic, see What Is Glutathione Good For Skin