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Third, we searched for our 247 new species in the 239 human gut microbiome samples from healthy individuals described by Browne et al

Notably, the glymphatic system, a recently characterized brain-wide waste clearance pathway pivotal for the removal of metabolic by-products like amyloid- and whose dysfunction is heavily implicated in neurodegenerative diseases, shows significant impairment in chronic tinnitus patients (Du et al., 2025)

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In addition, levels of Toll Like Receptor 4 (TLR4) and inflammatory factors, such as Nuclear Factor B (NF-B), IL-6 and Monocyte Chemoattractant Protein-1 (MCP-1), were also significantly decreased compared to the untreated PE group

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