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In situ immunolocalization has been used to examine glutathione distribution at the subcellular level by quantitative immunohistochemistry coupled to electron microscopy (Figure 2B)
It has been implicated in various pathological conditions, including stroke (30)
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RPI promotes tumor growth and colony formation by negatively modulating protein phosphatase 2A (PP2A) to activate extracellular signal-regulated kinase (ERK) signaling pathways (100)
The Phase 2 trial primarily tested oral administration
Necrotic core formation and plaque rupture During the process of intravascular adipose streaks formation or pathological intimal thickening, inflammatory ECs and macrophages attract more monocytes to infiltrate the intima by secreting chemokines such as CCR2, CCR5, CXCR1, and CXCR2 [87, 88]
