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The stimulant buthionine sulfoximine (BSO) irreversibly inhibits the activity of -glutamate cysteine synthetase, which is a rate-limiting enzyme in GSH synthesis in RAS mutant cells

Acute GVHD results in a severe DC defect that prevents T-cell priming and leads to fulminant cytomegalovirus disease in mice

In the context of therapeutic interventions, van San et al

Carotenoids may upregulate the activity of antioxidant enzymes, mainly via the activation of the Nuclear factor erythroid 2-related factor 2 (Nrf2)-dependent pathway (Kaulmann and Bohn 2014)

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