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[6] Cytotoxic Payloads The cytotoxic payload is a critical component of ADCs responsible for exerting cytotoxic effects, necessitating several key requirements: (1) high cytotoxicity, typically with IC50 values at low nanomolar or picomolar levels (Figure 7)

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Amylins Role in Diabetes and Obesity In T1DM, amylin basal levels are reduced, and the postprandial secretion is diminished [38]

Most of the intracellular DNA was disrupted within 200-1000 bp by ultrasound

Although CAT and GPX share common substrates, CAT has a much lower affinity for H 2 O 2 at low concentrations compared with GPX (i.e., GPX K m = 1 M vs