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Probiotics play a crucial role in modulating prostaglandin E2 (PGE2), an anti-inflammatory prostanoid that inhibits the secretion of pro-inflammatory cytokines, such as IL-1 and TNF-, by macrophages (174)

These NAC doses (200600) are safe, and there is evidence showing that the LD50 of NAC in rats is 1205 mg/kg [28]

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In spermatozoa, this translates into defective motility, premature capacitation, and increased susceptibility to apoptosis-like changes (39, 45)
