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Ethacrynic Acid and Its Derivatives Ethacrynic acid (EA), Figure 6A, was first developed in 1963 as a potent diuretic for the treatment of patients with hypertension and intractable edema [152,153,154]

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[DOI] [PubMed] [Google Scholar] 46.Richter-Landsberg C., Heinrich M

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In addition, DCA treatment alone caused ER stress to an extent that was nearly as robust as the bona fide ER stressor TM, as seen by splicing of Xbp1 (Figure 7F) and upregulation of UPR target genes (Figure 7G)