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3D, E), indicating that combined loss of PHD2 and GSTP1 drives a coordinated, systems-level shift toward growth arrest and cell death that exceeds the effects of either perturbation alone, with potentially lethal consequences for cellular viability

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ACSL4-ALOX15 synergy accelerates lipid peroxidation, creating a self-amplifying toxic loop [96]

doi: 10.1093/nar/gnh159 [DOI] [PMC free article] [PubMed] [Google Scholar] 69

Caspases: the enzymes of death