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Description
This effect is stark in HF with preserved ejection fraction (HFpEF), where stiff ventricles increase pressures during exertion, causing ventilationperfusion (VQ) mismatch and reduced exercise tolerance, often exacerbated by pulmonary arteriolar remodeling
Ischemic and non-ischemic acute kidney injury cause hepatic damage

Curcumins therapeutic effects are attributed to its multifactorial mechanisms, including inhibition of hepatic fat synthesis, modulation of lipid profiles, and reduction of oxidative stress and inflammation (Mukhopadhyay et al., 2014
resistance results from mutations in ergosterol biosynthetic genes

Unger et al

Ikemoto et al., 2024)