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Non-enzymatic antioxidants remain essential with their diverse mechanisms and compartment-specific protection, but face limitations that hydrogen water's properties effectively address, with evidence suggesting hydrogen may even enhance endogenous antioxidant systems through Nrf2 pathway activation

N-acetylcysteine, or NAC, is a supplement that works in two ways: It provides cysteine, which is the rate-limiting amino acid for glutathione production It can also act as a direct antioxidant to scavenge ROS (NO2 and HOX)[ref][ref] The main antioxidant mechanism for NAC is by increasing glutathione levels

Yet, this combo is best used under medical guidance

But what if there was one?" The reality is more nuanced