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2022 Aug;16(8):767785

Preserving muscle while losing fat is a major therapeutic goal in obesity medicine, as loss of muscle mass can worsen metabolic function and long-term outcomes

[DOI] [PubMed] [Google Scholar] 221.Simpson DSA, Oliver PL

Khan MA, Pace-Asciak C, Al-Hassan JM, Afzal M, Liu YF, Oommen S, et al

And then how long does it last

Thus, Kpffer cells are main actors in the immune response against endotoxin/lipopolysaccharide (LPS) via Toll-Like Receptor type 4 (TLR4) signaling pathway leading to the production of pro-inflammatory mediators such as cytokines (TNF-, interleukin [IL]-1, IL-6), chemokines (monocyte chemotactic protein-1 [MCP-1]), ROS and profibrogenic factors (transforming growth factor [TGF]-, platelet-derived growth factor [PDGF]), which subsequently activate hepatic stellate cells for the production of extracellular matrix (Jeong&Gao, 2008) (Gao et al, 2011) (Figure 5)