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Description
Investigations suggest that this interaction may stimulate periodic bursts of growth hormone release through intracellular signaling events

It mimics ghrelin and binds to the ghrelin receptor (GHSR) in the brain, selectively stimulating GH release from the pituitary gland, which increases plasma GH levels

Peptides are short chains of amino acids, the building blocks of proteins, linked together by peptide bonds

What they did: n 536 adults with obesity (BMI 30 to 45)

First, since HSL is apparently the primary diacylglycerol lipase in adipose tissue, the accumulation of diacylglycerol in WAT of HSL null mice might interfere with normal adipocyte differentiation or function through the activation of protein kinase C family members and their downstream targets, which are known to affect cell proliferation, apoptosis, and differentiation (Figure 2A)

The receptor is part of the machinery through which a chronic lipolytic phenotype is expressed and its expression is upregulated by the peptide but the peptides acute lipolytic and thermogenic effects can proceed without it
