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Additionally, increased copper levels can decrease the activities of antioxidant enzymes, including SOD, total antioxidant capacity, GSH peroxidase (GSH-Px), and catalase, in both serum and heart tissue while also lowering the levels of the nonenzymatic antioxidant GSH (Skrajnowska et al., 2013

In this regard, MitoQ, an antioxidant that targets mitochondria, has been shown to decrease the expression of TGF-1 and NOX4 in IPF pulmonary fibroblasts [154]

[DOI] [PubMed] [Google Scholar] 25.Radi R, Peluffo G, Alvarez MN, Naviliat M, Cayota A

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