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Aloxe3 Knockout Mice Reveal a Function of Epidermal Lipoxygenase-3 as Hepoxilin Synthase and Its Pivotal Role in Barrier Formation

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Key Points Direct-acting antiviral agents targeting the viral NS3/4A protease, NS5B polymerase and NS5A protein have been developed Combinations of antiviral agents with different mechanism of action lead to high rates of sustained virologic response without the need for PEG-IFN Classes of direct-acting antiviral agents have different antiviral attributes such as barrier to resistance and genotypic coverage, and different clinical attributes such as adverse effects, dosing, and drugdrug interactions The importance of resistance-associated variants present at baseline or after a course of unsuccessful therapy differs by antiviral class and the genotype subtype Abstract The treatment of HCV infection has evolved at an extremely rapid pace over the past few years

Thirdly, the mechanism of action of MOTS-c on bone metabolism has been under-investigated, and most studies focus on the ex vivo mechanism, and fewer on the in vivo mechanism

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