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Short exposure of oesophageal mucosa to bile acids, both in acidic and weakly acidic conditions, can impair mucosal integrity and provoke dilated intercellular spaces

Insert the needle at a 45- to 90-degree angle in a quick, smooth motion

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A seminal cost analysis published in Canadian Family Physician (2001) projected that switching patients from intramuscular B12 injections to oral supplements could save between $2.9 million and $17.6 million depending on the population studied with one Ontario analysis estimating $14.5 million in savings for 110,000 elderly patients