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ChIP demonstrated decreased occupancy of all three marks at DSBs in IDH1i-treated cells in addition to increased H2AX ( Fig

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Moreover, a similar level of reduction of CoQ 10 levels in 4-NB-treated T67 human glioma cells (by 50%) was demonstrated to cause higher cellular and mitochondrial oxidative stress (demonstrated by increased DCFH-DA and MitoSOX signals) as well as an elevation of nitric oxide (NO ) levels (338)

doi: 10.1002/art.38053 186 PanulaHELohmanderLSRonkkoSAgrenUHelminenHJKivirantaI

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