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347 ADH-6 stabilizes the p53 R248W mutant by interacting with the p53 core domain, preventing the formation of these aggregates

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Furthermore, treatment of rat hippocampal cells and SHSY5Y human neuroblastoma cells with H 2 O 2 at the early stages of oxidative stress exposure results in tau dephosphorylation at the tau1 epitope by CDK5 via Pin1 activation (203)

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However, it's important to note that NICE guidelines for heart failure (NG106) and myocardial infarction do not currently recommend routine supplementation with either CoQ10 or L-carnitine, and these agents should not replace evidence-based pharmacological treatments