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Characterization- and formulation-associated issues include the correlation of in vitro model with in vivo studies, the usage of a high amount of surfactant, the precipitation of drug in vivo, the oxidation potential of lipid components, the difficulty of low encapsulation, etc

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For our rapid refolding method, the pellet was dissolved in dissolving buffer (10 mM Tris, 100 mM NaH 2 PO 4 , pH 8.0, and 8 M urea) for 2 hours at 4 C while stirring

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(2022) found that aminoglycosides bind to and trigger rapid translocation of Rho family interacting cell polarization regulator 2 (RIPOR2) in cochlear hair cells from the stereocilia to the pericuticular area, which interacts with the core autophagy component GABARAP and affects autophagy activation

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