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12,14 vaginal itching, burning, and irritation pain with intercourse and sexual dysfunction urinary frequency, urgency, pain, and incontinence recurring vaginal and urinary tract infections Hot Flashes and Night Sweats (Vasomotor Symptoms) About 80% of women report experiencing vasomotor menopause symptoms, usually beginning years before and persisting for years after their last menstrual period

JAMA 295 , 15391548 (2006)

However, some comparative studies in animals suggest that oral ingestion of the peptide can also have systemic effects

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(Qiu et al., 2023) reported low levels of NAD + in the aorta from hypertensive patients showing that supplementation with NAD + precursors effectively lowered blood pressure and improved impaired vascular function in both hypertensive patients and mice

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