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Nagane et al., 2018

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We direct specific attention to variants Var2, Var12, and Var15, and speculate about several possible functional implications at the molecular level in AN pathobiology

The condition involves dysregulation of neurotransmitters, inflammatory mediators, and stress response systems, producing a constellation of symptoms extending far beyond pain to include crushing fatigue, unrefreshing sleep, cognitive dysfunction known as fibro fog, and heightened sensitivity to temperature, sound, and light