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As mentioned above, a normal microbiota regulates various aspects of epithelial barrier function, such as TJ expression, angiogenesis, vascular permeability and immunomodulation [2, 37]

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Hippocampal gene expression is highly responsive to estradiol replacement in middle-aged female rats

doi: 10.1021/Bi00075a026 15 CutrinJCZingaroBCamandolaSBoverisAPompellaAPoliG

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As the ASCO panel noted, Although proof of benefit has not been provided, data suggestive of benefit support that 3 approaches (scrambler therapy, acupuncture, and exercise) may diminish established CIPN symptoms and appear to be reasonably safe. Nonetheless, they emphasised the need for further research to clarify the effectiveness of these therapies, acknowledging that while the evidence remains inconclusive, these interventions may still provide relief for some patients