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Nonetheless, the reasons for these differences are unclear, other than the obvious alternative splicing of Grx2 transcripts and the absence of a translocation signal in Grx1 transcripts

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The proton is then poised to polarise the resulting Cys58-substrate mixed disulphide bond, making it vulnerable to attack from Cys63 to return the enzyme to its rest state

NADPH is primarily generated by three main cellular metabolic sources: the oxidative pentose phosphate pathway (oxPPP), malic enzyme, and serine-derived one carbon metabolism 37

The Close Link Between IronSulfur (Fe/S) Clusters and Genome Integrity Mitochondria are organelles with a double-layer membrane found in most eukaryotic organisms

Recent studies suggest that it may also have the ability to correct calcium imbalances