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Veldhuis et al., 2005

Glutaminase-2 (GLS2), the enzyme crucially induced in A-T cerebellar tissues 67 , promotes glutamine dependence as the major bioenergetic fuel in the mitochondira 68

Accumulated data indicates its key role in protein homeostasis and other diverse functions involved in various ocular diseases, such as glaucoma, diabetic retinopathy, age-related macular degeneration, retinitis pigmentosa, achromatopsia, cataracts, ocular tumors, ocular surface diseases, and myopia

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[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Zhu H., Chan K.T., Huang X., Cerra C., Blake S., Trigos A.S., Anderson D., Creek D.J., De Souza D.P., Wang X., et al