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Whether chronic use affects normal age-related changes in metabolism, body composition, or health cannot be determined from current data

Research shows that NNMT overexpression in adipose tissue creates a metabolic environment that favors lipid accumulation by depleting the very cofactors needed for efficient fatty acid oxidation

Bain MD, Jones M, Borriello SP, et al

Semaglutide is a synthetic GLP-1 RA (receptor agonist)

This decline correlates with reduced wound healing capacity, decreased collagen synthesis, and visible skin aging
