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In addition, it does not exclude the possibility that the conformational changes of the polymerase through rhythmic relaxation and contraction, also known as molecular respiration, facilitates the template RNA to be continuously squeezed into the catalytic pocket and also plays a role in the translocation of the template during RNA synthesis

2007;293:L446452

Studies show that the transcription factor FOXO4 plays a protective role in senescent cells by maintaining the protein p53 in a sequestrated state within nuclear structures, thereby inhibiting its ability to initiate apoptosis