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[141] Although there have been sporadic synthetic efforts since 1972, [140] the EschenmoserWoodward synthesis remains the only completed (formal) total synthesis

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Clinical evidence indicating accelerated antidepressant response, improved cognition, enhanced sleep architecture, and reduced biomarkers of neuronal injury in elderly and medically comorbid populations underscores its relevance in late-life depression and depression associated with cognitive or vascular dysfunction (96)

Oxid Med Cell Longev 2019:7286737

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