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Some individuals may struggle to absorb enough B12 from their diet, especially those with conditions like pernicious anemia, certain gastrointestinal disorders, or those taking medications that impact absorption

When you take it by mouth, B12 has to navigate your complex digestive system before reaching your bloodstream

Those pregnant, breastfeeding, or undergoing cancer treatment should avoid it until more data becomes available

Chasan-Taber L et al., Arch Intern Med 2009 Folate, B6, B12 supplementation and AMD risk

It does not affect cholesterol profiles negatively

So, while the idea that B12 injections cause weight gain might be a popular rumor, current evidence indicates that a vitamin B12 deficiency is unlikely to affect your weight directly in terms of gain