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First, growth hormones fat-mobilizing effect is coupled, in the intact hormone, to metabolically costly side effects: the same signaling that liberates fatty acids also raises circulating IGF-1 and can worsen insulin sensitivity, which is precisely why chronic growth-hormone administration is not a benign way to lose fat

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Naik et al

Off-Label Prescribing Does Not Apply Off-label prescribing applies to drugs that have FDA approval for at least one indication

Arango, M.-T

However, systemic copper loading remains a theoretical concern requiring careful dose optimization and copper status monitoring, particularly with chronic administration protocols