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In cells where GCLC predominates, this mechanism may allow increased GSH synthesis by increasing the enzymatic activity of monomeric GCLC

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Nanotechnology-based carriers, receptor-targeted delivery platforms, intranasal nanoparticle systems, and extracellular vesicle-based formulations have demonstrated improved pharmacokinetics, controlled release, and enhanced CNS accumulation in preclinical studies, with several advanced platforms now progressing into early-phase clinical evaluation for AD and related neurodegenerative disorders

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PLoS Comput Biol 13:e1005752

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Investigative Ophthalmology & Visual Science, 59 , 44414448

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