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Description

The HPLC gradient grade acetonitrile (ACN), used for chromatographic analysis, hydrochloric acid utilized for the standard solution preparation, sodium hydrogen phosphate heptahydrate (Na 2 HPO 4 7H 2 O), sodium dihydrogen phosphate dihydrate (NaH 2 PO 4 2H 2 O) and sodium hydroxide were purchased from J.T

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Safety and efficacy hinge on careful dose management, appropriate patient selection, and adherence to clinical guidelines

Tips

In a 2024 phase I trial (n = 72), VENT-03 demonstrated good tolerability and robust pharmacodynamic signals, achieving complete in vivo cGAS target inhibition and laying the foundation for phase II studies in mtDNA-driven diseases such as systemic lupus erythematosus (SLE) (Pike et al., 2024)