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doi: 10.1111/j.1939-165X.2005.tb00041.x

Abstract Pyruvate kinase deficiency (PKD) is the most common cause of chronic hereditary non-spherocytic hemolytic anemia and results in a broad spectrum of disease

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From the periconceptional environment to birth For most genes, total reprogramming is necessary very soon after conception in order to start with an epigenetic clean slate, which then allows all of the specialized cells derived from the egg and sperm to develop with stable cell-specific gene expression profiles and remain properly differentiated