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Mutation-Directed Therapeutics for Neurofibromatosis Type I

This evidence highlights the importance of PTM in inflammatory autoimmune conditions and their potential use as biomarkers for early diagnosis and disease stratification

10.1016/j.sajb.2024.07.048 114 KummerJ

Cereblon-based PROTACs: factors influencing efficacy The efficacy of cereblon-based PROTACs depends directly on the absence of mutations that interfere with the binding of the degrader to the protein, or indirectly, on mutations that interfere with the formation of the E3 ubiquitin ligase CRL4 CRBN complex, such as mutations that interfere with the binding between cereblon and the DDB1 protein

The control group continued with only the current treatment but Meriva (2 500 mg/day-totalling 200 mg curcumin) was added to the study group

It is advisable to continue with maintenance doses even though you have achieved the skin tone for long-term results