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MCP-1, CXCL10, RANTES, and eotaxin increased in the IC/BPS group

Contrary to the long-lasting belief that IBS is not associated with organic changes, there is now growing evidence supporting that structural, although subtle, changes may be found in the gastrointestinal tract of large subgroups of these patients (197)

Lactobacillus rhamnosus CY12 enhances intestinal barrier function by regulating tight junction protein expression, oxidative stress, and inflammation response in lipopolysaccharide-induced Caco-2 cells

If your particular GP is unhelpful, could there be another in the practice who you could see instead