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2016 Apr;241(8):783-99

Radbruch et al

Ketone bodies and two-compartment tumor metabolism: stromal ketone production fuels mitochondrial biogenesis in epithelial cancer cells

PMID: Summary Keywords drug-induced liver injury, StevensJohnson syndrome, toxic epidermal necrolysis, immune checkpoint inhibitors, moxifloxacin Citation Li Q, Wang L, Xu H, Huang T, Hong H, Ji X and Liu J (2026) Concurrent moxifloxacin-induced liver injury and toxic epidermal necrolysis after immune checkpoint inhibition: a case report and literature review

found that the lncRNA CRNDE triggers protective autophagy by upregulating ATG4B in HCC cells via sequestration of miR-543, whereas sorafenib therapy activates the CRNDE/ATG4B/autophagy pathway and reduces sorafenib sensitivity in HCC [86]

Continued studies on OTA led to the observation that oxidative stress was a possible key factor in the toxicity and genotoxicity of OTA [23,24,25,26]
