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Most patients notice the most visible improvements approximately 30 days after beginning treatment including improvements in energy, metabolic function, and initial weight changes

About 10% of people do not lose weight when they take GLP-1 weight-loss medications

Carotene levels improved, but were still somewhat low, so higher amounts are needed

doi: 10.1016/j.freeradbiomed.2010.02.038

While early and smaller trials showed promising fat-loss effects, the largest Phase IIb trial did not achieve statistical significance in humans for its primary endpoint of weight reduction, which led to the program being discontinued

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