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However, rates of deaths involving other opioids, specifically heroin and synthetic opioids other than methadone (likely driven primarily by illicitly manufactured fentanyl) (2,3), increased sharply overall and across many states." Rudd RA, Seth P, David F, Scholl L

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Keywords: heavy AOD use, alcoholic liver cirrhosis, alcoholic hepatitis, ethanol metabolism, biochemical mechanism, toxic drug effect, inflammation, drug therapy, hereditary factors, gender differences, diet, risk factors, endotoxin, fibrosis, free radicals, etiology, literature review An association between liver disease and heavy alcohol consumption was recognized more than 200 years ago (Smart and Mann 1992)