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By blocking NNMT, 5-Amino-1MQ increases NAD+ levels and activates SIRT1, the longevity gene, promoting fat loss, energy production, and metabolic rejuvenation

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Research progress Support The animal experiments have achieved remarkable results: In the obese mouse model, after daily subcutaneous injection of AOD 9604 (250 g/kg) for 8 weeks, the body weight of the mice decreased by 12%, the subcutaneous fat mass decreased by 25%, and the weight of epididymal adipose tissue significantly decreased, confirming its effectiveness in fat reduction

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In the liver, where CD38 expression marks the tissue-resident viral-specific CD8 + T cells, a lesser distinction between the different infection types was observed (Supplemental Figure 5D)