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[DOI] [PMC free article] [PubMed] [Google Scholar] 94.Kowalczyk P., Sulejczak D., Kleczkowska P., Bukowska-Osko I., Kucia M., Popiel M., Wietrak E., Kramkowski K., Wrzosek K., Kaczynska K

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[183] showed that HRS reduces apoptosis induced by skin I/R and improves flap survival modulation of the Bax/Bcl2 ratio and inhibition of the activated Apoptosis SignalRegulating Kinase 1/JNK pathway

When applied topically, vitamin C converts chlorine and chloramines on the skin into the harmless compounds dehydroascorbic acid and hydrochloric acid (8,9)

Inactivation of one or more of these mechanisms causes unchecked lipid peroxidation, compromising membrane integrity and triggering ferroptosis

A study by Holton et al