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Another study reported that MIEN1, potassium calcium-activated channel subfamily N member 3 (KCNN3), and drug resistance in ovarian cancer are significantly associated with each other [120]

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By applying transcriptome sequencing to determine the possible pharmaceutical target of N-methyl-N-nitrosourea (MNU)-induced mouse models, researchers ascertained that ubiquitination and degradation of GPX4, catalyzed by Cullin-7, resulted in PR ferroptosis (112)

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