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Mechanisms of drug resistance include epithelial-mesenchymal transition, DNA repair activation, reduced drug uptake, enhanced drug efflux, changes in pro-apoptotic and anti-apoptotic genes, changes in tumor cell microenvironment, and redox imbalance
Reduces DNA damage caused by radiation exposure

If you're designing a protocol around the assumption that short half life equals short effect, you're applying the wrong framework entirely

[Google Scholar] 4.Mukherjee KK, Lee AY, Zhu L, Darvas M, & Ladiges W

Theory of protein folding: The energy landscape perspective
