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Additionally, ALA should never be administered to patients with an unaddressed thiamine (vitamin B1) deficiency, such as those with severe alcohol use disorder, as ALA requires thiamine to function

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A hierarchical system of cellular surveillance mechanisms protects mitochondria against stress and damage, hence ensures the selective removal of dysfunctional mitochondrial proteins

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The duration of prescription use ranged from 2 to 178 months, with a mean of 37.4 months (SD 37.3) (Fig
