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Phosphodiesterase 4 (PDE4) inhibitors in asthma and chronic obstructive pulmonary disease (COPD)

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Nevertheless, even when pharmacokinetics is unaffected, the concomitant ingestion of alcohol and benzodiazepine can have synergistic sedative effects, suggesting that pharmacodynamic effects are at play (270, 271)

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van de Donk N, Richardson PG, Malavasi F

We have seen a reassuring rise or normalisation in SHBG with microdosing
