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It should be noted that there is a lack of research assessing the costbenefit analysis of periodic monitoring of vitamin B12 in those taking metformin, though it is a relatively inexpensive test to undertake

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J Neurochemistry 35:12421245 Kumar C, Igbaria A, D'Autreaux B, Planson AG, Junot C, Godat E, Bachhawat AK, Delaunay-Moisan A, Toledano MB (2011) Glutathione revisited: a vital function in iron metabolism and ancillary role in thiol-redox control