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Large databases exist that should allow discernment of types of adverse reactions between men and women but these should consider age, hormonal status, specific medication/probe drug used, and interindividual variation in enzyme activity due to genetic variation

doi: 10.1186/s12985-016-0663-7 75 Van ButselaarT.Van den AckervekenG

The role of oxidative stress in the COVID-19 disease may involve recognition of the viral S-protein by angiotensin converting enzyme-2 (ACE2) receptor and pattern recognition receptors like toll-like receptors 2 and 4, and activation of transcription factors like nuclear factor kappa B, that subsequently activate nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) expression succeeded by ROS production (Kozlov et al., 2021)