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Zhou, J., Zhuang, Z., Li, J

doi:10.1046/j.1524-475X.1994.20406.x Leyden J, Stephens T, Finkey MB, Barkovic S, Schweiger D

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This suggests that the dose-escalation schedule used for the 36 mg arm may have been somewhat better optimized to mitigate nausea than the schedule for the 12 mg arm, or that the higher dose groups achieved better gastrointestinal adaptation during the titration period