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Androgen stimulates glycolysis for de novo lipid synthesis by increasing the activities of hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 in prostate cancer cells

-Butyrobetaine is then converted to L-carnitine in a reaction catalyzed by -butyrobetaine dioxygenase, an enzyme that is only expressed in kidney, liver, and brain [40, 41]

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Acetyl L-Carnitine transports fats to brain cell mitochondria for energy, helping to prevent brain cell death and supporting optimal neurological health.*

The process likely requires the involvement of multiple genetic driver alterations intimately linked with prostate cancer progression, effective inhibition of the AR signaling axis, and time to enable the downstream epigenetic effectors to continuously reprogram the transcriptome of cancer cells depending on conditions [47] (Fig

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